According to the Geological settings and the distributed laws of ore bodies and previous research results, combining with latest theories and new methods of geological prospecting, the authors proposed prospecting thoughts for substituted resources in Laozuoshan gold deposit. After ore prospecting in two years, nine new blind ore bodies were found, among which four ore bodies contain 4218.1 kg inferred intrinsic economic resources (333), and mitigate the crisis situation of mine reserves. At the same time, lots of significant geophysical and geochemical anomalies were found in the peripheral, which provide a basis for further prospecting. According to the Geological settings and the distributed laws of ore bodies and previous research results, combining with latest theories and new methods of geological prospecting, the authors suggested prospecting thoughts for substituted resources in Laozuoshan gold deposit. After ore prospecting in two years, nine new blind ore bodies were found, among which four ore bodies contain 4218.1 kg inferred intrinsic economic resources (333), and mitigate the crisis situation of mine reserves. At the same time, lots of significant geophysical and geochemical anomalies were found in the peripheral, which provide a basis for further prospecting.