1病例2009年4月至2015年9月,我研究室发现的4例表型正常男性的纯合型额外小染色体,现报告如下:例1:男,30岁,结婚4年,其妻孕2产0,均在孕3个月内停止发育;非近亲结婚,夫妻表型智力正常,各项生殖检查皆正常,其中精液检查正常。染色体检查:核型为47,XY,+mar,妻子核型正常,妇科检查无异常。例2:男,33岁,结婚3年,其妻孕3产0,均在孕 1 cases from April 2009 to September 2015, I found in the laboratory of 4 cases of normal male homozygous additional small chromosomes, are reported as follows: Example 1: Male, 30 years old, married 4 years, his wife’s pregnancy 2 0, were stopped within 3 months of pregnancy; non-relatives married, husband and wife phenotype normal intelligence, the reproductive tests are normal, including normal semen examination. Chromosome examination: Karyotype 47, XY, + mar, wife karyotypes normal, no abnormal gynecological examination. Example 2: Male, 33 years old, married 3 years, his wife 3 pregnant 0, are pregnant