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盘状红斑狼疮(DLE)和扁平苔藓(LP)的典型损害无论在临床或病理方面都不难以鉴别。然而,鉴别DLE和LP的不典型损害却存在一定困难,即使进行活体组织切片检查亦有三分之一标本不能区分。因此,需要采用更好的诊断方法及取得更多的诊断依据。近年来,通过直接法免疫荧光研究显示50—94％的DLE在损害部位基底膜区有免疫球蛋白(Ig)沉积,而仅有0—9％的LP在损害部位基底膜区出现Ig沉积,说明DLE和LP在Ig方面有一定差别,从而为DLE
Typical lesions of discoid lupus erythematosus (DLE) and lichen planus (LP) are not difficult to identify clinically or pathologically. However, there are certain difficulties in identifying the atypical lesions of DLE and LP, and even one-third of biopsy specimens cannot be distinguished. Therefore, it is necessary to adopt better diagnostic methods and obtain more diagnostic evidence. In recent years, direct immunofluorescence studies have shown that 50-94% of DLE have immunoglobulin (Ig) deposition in the basement membrane of the lesion, and only 0-9% of LP have Ig deposition in the basement membrane of the lesion. Explain that DLE and LP have some differences in Ig, which is DLE