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目的研究茅莓根的化学成分。方法利用硅胶、Sephadex LH-20柱色谱、半制备高效液相色谱等分离技术。结果从茅莓根的乙醇提取物中分离鉴定19个化合物。通过理化性质及波谱数据分析,其化合物结构分别鉴定为:对羟基苯甲酸(1),4-羟基-3,5-二甲氧基苯甲酸(2),3-甲氧基-4-羟基苯甲酸(3),β-谷甾醇(4),齐墩果酸(5),乌苏酸(6),2-oxo-坡模酸(7),坡模酸(8),对羟基苯乙醇(9),psiguanin A(10),2α-羟基熊果酸(11),委陵菜酸(12),2α,3α,19α,23-四羟基乌苏-12-烯-28-羧酸(13),表儿茶素(14),2α,3α,19α,24-四羟基齐墩果-12-烯-28-羧酸(15),2α,3α,19α,24-四羟基乌苏-12-烯-28-羧酸(16),2α,3β,19α-三羟基齐墩果-12-烯-23,28-二羧酸(17),悬钩子皂苷R1(18)和β-胡萝卜苷(19)。结论化合物1~3,5,7~10,12,15~17为首次从茅莓根中分离得到,化合物7,9为首次从悬钩子属植物中分离得到,化合物10,15~17为首次从蔷薇科植物中分离得到。
Objective To study the chemical constituents of the roots of Mao-Mao. Methods Silica gel, Sephadex LH-20 column chromatography, semi-preparative high performance liquid chromatography and other separation techniques. Results Nineteen compounds were isolated and identified from the ethanolic extracts of the roots of Mao. The structures of the compounds were identified as: (1), 4-hydroxy-3,5-dimethoxybenzoic acid (2), 3-methoxy-4-hydroxy (3), β-sitosterol (4), oleanolic acid (5), ursolic acid (6), 2-oxo- Ethanol (9), psiguanin A (10), 2α-hydroxy ursolic acid (11), ceilin acid (12), 2α, 3α, 19α, 23-tetrahydroxysusu-12-ene- (13), epicatechin (14), 2α, 3α, 19α, 24-tetrahydroxyolean-12-ene- 28-carboxylic acid (15), 2α, 3α, 19α, 24- Alpha] -trihydroxyolean-12-ene-23,28-dicarboxylic acid (17), rubusoside R1 (18) and beta- Daucosterol (19). Conclusions Compounds 1, 3, 5, 7-10, 12 and 15-17 were isolated from the roots of ramets for the first time. Compounds 7 and 9 were isolated from Rubus for the first time. Compounds 10 and 15-17 were the first Isolated from the Rosaceae plants.