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关于柑桔类果实使用防腐剂后病原菌的耐药性问题早已被提了出来。在五十年代国外广泛使用邻苯基酚钠(Sopp)和联苯之前的四十年代,Farkas等人(1940)就已通过试验获得了对联苯表现出耐性的绿霉病菌。Littauér等(1953)和Harding(1959)也曾分别报导过蒂腐病菌和青露病菌在离体培养中
The question of resistance to pathogens after the use of preservatives on citrus fruits has long been raised. F40 (1940) had previously obtained green mold fungi that showed resistance to biphenyls by the 1940s, before the widespread use of sodium orthophenate (SOPs) and biphenyls abroad in the 1950s. Littauér et al. (1953) and Harding (1959) also reported on the pathogen in vitro culture