酒精性肝病(alcoholic liver disease,ALD)是由于长期大量饮酒所致的慢性肝病。初期通常表现为脂肪肝,进而可发展成酒精性肝炎、肝纤维化和肝硬化(alcoholic cirrhosis,AC)。近年来,我国ALD发病率逐渐上升,但其发病机制尚未完全阐明。较多研究认为,细胞因子参与了ALD的发病机制,其中核因子κB(nuclear factor-kappa-B,NF-κB)和转化生长因子-β(transforming growth factor-β,TGF-β)与ALD的进展关系密切,本文对它们在ALD发生过程中所起的作用简要综述。 Alcoholic liver disease (ALD) is a chronic liver disease caused by prolonged heavy drinking. The initial stage is usually manifested as fatty liver, which can develop into alcoholic hepatitis, liver fibrosis and cirrhosis (alcoholic cirrhosis, AC). In recent years, the incidence of ALD gradually increased, but the pathogenesis has not been fully elucidated. More studies suggest that cytokines are involved in the pathogenesis of ALD, in which nuclear factor-kappa-B (NF-κB) and transforming growth factor-β (TGF-β) Progress is closely related to this article on their role in the occurrence of ALD during a brief review.