目的：９９ｍ　 Ｔｃ Ｍ Ｉ Ｂ Ｉ可被具代谢活性的肿瘤细胞被动摄取且可在 Ｐ糖蛋白（ Ｐｇｐ）作用下被泵出肿瘤细胞。 Ｐｇｐ 是一种分子量为 １７０ｋｕ 的膜蛋白，被 Ｍ Ｄ Ｒ１ 基因编码，是某些抗肿瘤药物的能量依赖性的流出泵。因此，９９ｍ　 Ｔｃ Ｍ Ｉ Ｂ Ｉ Ｓ Ｐ Ｅ Ｃ Ｔ 是否可以预测肿瘤患者的化疗反应受到关注。方法：选择 １６ 例未经化疗和４ 例已接受化疗的脑肿瘤患者行９９ｍ　 Ｔｃ Ｍ Ｉ Ｂ Ｉ Ｓ Ｐ Ｅ Ｃ Ｔ 显像，并参照磁共振显像，与２０１　 Ｔｌ Ｓ Ｐ Ｅ Ｃ Ｔ 显像进行比较。考察肿瘤的 Ｍ Ｄ Ｒ１ 基因表达及 Ｐｇｐ 含量， 并与９９ｍ　 Ｔｃ Ｍ Ｉ Ｂ Ｉ Ｓ Ｐ Ｅ Ｃ Ｔ 比较。结果：９９ｍ　 Ｔｃ Ｍ Ｉ Ｂ Ｉ与 ２０１　 Ｔｌ一样，在恶性胶质瘤区浓聚并潴留。９９ｍ　 Ｔｃ Ｍ Ｉ Ｂ Ｉ的影像比２０１　 Ｔｌ 清晰，对比度好。半定量分析示未经治疗患者早期摄取指数（ Ｕ Ｉ，早期病变处与对侧区域的平均计数／象素的比值）与恶性度有关。低分化胶质瘤为 １０８±００６，未分化星形细胞瘤为 ４１０±０８４，胶质瘤为 ５７１±３４７，脑转移瘤为 ７５２±１５２。脑转移瘤患者的９９ｍ　 Ｔｃ Ｍ Ｉ Ｂ Ｉ潴留指数 Objective: 99m Tc M I B I can be passively metabolized by tumor cells and can be pumped out of tumor cells under the action of P-glycoprotein (Pgp). Pgp is a membrane protein with a molecular weight of 170 ku, encoded by the M DR-1 gene and an energy-dependent efflux pump for certain anti-tumor drugs. Therefore, whether 99m Tc M I B I S P E C T can predict chemotherapy response in cancer patients has drawn attention. Methods: Totally 99m Tc-M I B I S P E C T imaging was performed in 16 patients without chemotherapy and in 4 patients who had undergone chemotherapy. MRI was compared with magnetic resonance imaging and with 201 Tl S P E C T Like to compare. M D R 1 tumor gene expression and Pgp content, and 99m Tc M I B I S P E C T comparison. RESULTS: 99m Tc-M I B I, like 201 Tl, accumulated and retained in the glioblastoma area. 99m Tc M I B I image than 201 Tl clear, good contrast. Semiquantitative analysis showed that early untreated patients uptake index (UI, early lesion and the contralateral region of the average count / pixel ratio) and malignancy. Poorly differentiated glioma was 1  08 ± 0  06, undifferentiated astrocytoma was 4  10 ± 0  84, glioma was 5  71 ± 3  47, brain metastases was 7  52 ± 1  52. 99m Tc M I B I retention index in patients with brain metastases