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目的分析围产期孕妇感染无乳链球菌(GBS)的流行病学特征和连续3年的耐药性监测结果,为临床制定有效的预防和治疗措施提供依据。方法回顾性分析2014年1月-2016年12月围产期孕妇的临床资料,按GBS阳性与阴性、孕妇的类型、文化层次、流产次数、年龄段和标本类型、季节、年度进行分组。结果 1 329例孕妇中共检出GBS携带者172例,检出率为12.9%;GBS阳性与阴性者的临床症状发生率、不同文化层次、不同年龄、不同年度围产期孕妇GBS检出率差异均有统计学意义(P<0.05)。GBS对青霉素G、氨苄西林、头孢唑林、头孢曲松和莫西沙星保持较低的耐药率,均<10.0%;未发现对万古霉素、利奈唑胺和亚胺培南的耐药株;对阿奇霉素、红霉素和克林霉素高度耐药,均>70.0%。D试验阳性率为32.7%。结论围产期孕妇GBS检出率较高,呈逐年上升趋势,GBS阳性者临床症状明显,高龄、文化层次低者易于感染,临床应重视GBS筛查并关注其耐药趋势。
Objective To analyze the epidemiological characteristics of Streptococcus agalactiae (GBS) in pregnant women during perinatal period and monitor the drug resistance for three years in a row, so as to provide basis for effective prevention and treatment measures. Methods The clinical data of pregnant women during perinatal period from January 2014 to December 2016 were analyzed retrospectively. The groups were divided into positive and negative GBS, type of pregnant women, culture level, number of abortion, age, type of specimen, season and year. Results A total of 172 cases of GBS carriers were detected in 1 329 pregnant women, the detection rate was 12.9%. The incidence of clinical symptoms of GBS positive and negative persons, the prevalence of GBS in different cultural levels, different ages and different years of perinatal pregnancy were different All were statistically significant (P <0.05). GBS maintained a low resistance rate to penicillin G, ampicillin, cefazolin, ceftriaxone and moxifloxacin, all <10.0%; no resistance to vancomycin, linezolid and imipenem was found Strain; azithromycin, erythromycin and clindamycin highly resistant, were> 70.0%. D test positive rate was 32.7%. Conclusion The detection rate of GBS in pregnant women during perinatal period is high, showing an increasing trend year by year. The clinical symptoms of GBS positive are obvious. The elderly with low cultural level are easily infected. GBS should pay attention to screening and pay attention to its drug resistance trend.