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三环类抗抑郁剂(TCA)引起的药疹已为人们所熟知。临床上,一旦发现严重的全身性皮疹,常规处理是即予停药,并将该药列为忌用范围。本文报告1例应用TCA后发生的药疹,在长达1yr余的时间内,应用多种其它药物治疗,其精神分裂症症状不能控制。为此,采用了特异性脱敏疗法获得成功,现报道如下。 患者,男,25yr,1986年12月5日因耳闻人语,强迫观念伴情绪低落2wk而首次住院。入院诊断:精神分裂症。于同年12月8日至12月29日单独服用氯米帕明(clomipramine)治疗,最大剂量为200mg/d。由于服药期间出现兴奋躁动而改用其它药物治疗,但病情仍不见改善,精神症状逐步演变成
Tricyclic antidepressants (TCA) caused by drug eruption has been well-known. Clinically, once a serious systemic rash is found, routine treatment is discontinued and the drug is considered a haven. This article reports on one case of drug eruption that occurred after TCA application and was used for many other medications over a 1-yr period of time, with no control of schizophrenia symptoms. To this end, the use of a specific desensitization therapy to achieve success, are reported below. Patients, male, 25yr, December 5, 1986 due to hear the tongue, obsessive compulsive mood for 2wk and the first hospitalization. Admission diagnosis: schizophrenia. In the same year December 8 to December 29 alone clomipramine (clomipramine) treatment, the maximum dose of 200mg / d. Because of medication during excitement and switch to other drug treatment, but the condition still did not improve, the mental symptoms gradually evolved into