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目的 通过分析胃肠胰神经内分泌肿瘤(GEP-NEN)患者99Tcm-HYNIC-TOC SPECT与68Ga-DOTA-TATE PET/CT显像结果,评估2种生长抑素受体(SSTR)显像方法的临床应用价值.方法 回顾性分析2013年5月至2014年2月于北京大学肿瘤医院行99Tcm-HYNIC-TOC SPECT和68Ga-DOTA-TATE PET/CT显像的34例GEP-NEN患者资料,患者均经病理学证实.其中男17例,女17例,年龄23～75岁.对比分析其显像结果,配对资料的比较采用x2检验,两样本均数的比较采用两样本t检验.结果 99Tcm-HYNIC-TOC显像阳性率为58.8％ (20/34),68Ga-DOTA-TATE显像阳性率为70.6％ (24/34),二者比较差异无统计学意义(x2=2.25,P＞0.05).而以受累系统为对象,2种显像方法检出率之间的差异具有统计学意义[9.5％ (29/306)和15.7％ (48/306);x2=17.50,P＜0.05],且差异主要表现在淋巴结、肝、骨等脏器.就肝脏病灶而言,99Tcm-HYNIC-TOC显像阳性和阴性病灶的短径和SUVmax比较,差异均具有统计学意义(t=4.4和3.2,均P＜0.05).结论 68Ga-DOTA-TATE PET/CT显像在探测小病灶及解剖结构相对复杂的病灶方面具有优势.“,”Objective To compare the diagnostic performances of 99Tcm-HYNIC-TOC SPECT and 68 Ga-DOTA-TATE PET/CT on patients with gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN).Methods From May 2013 to February 2014,34 patients (17 males,17 females;age:23-75 years) with histologically proven GEP-NEN were enrolled in the study.All patients underwent 99Tcm-HYNIC-TOC SPECT imaging and 68Ga-DOTA-TATE PET/CT imaging.x2 test and two-sample t test were used to analyze the data.Results The positive rate of 99Tcm-HYNIC-TOC imaging was 58.8％(20/34),which had no statistical difference with that of 68Ga-DOTA-TATE imaging (70.6％,24/34;x2 =2.25,P＞0.05).However,taking lesions as the target,the detection positive rate of 68Ga-DOTA-TATE imaging (15.7％,48/306) was statistically higher than that of 99Tcm-HYNIC-TOC imaging (9.5％,29/306;x2 =17.50,P＜0.05),especially for the lymph nodes,liver and skeleton lesions.For the liver lesions,the short diameter and SUVmax of 99Tcm-HYNIC-TOC positive lesions in the liver were statistically higher than those of negative lesions (t =4.4 and 3.2,both P＜0.05).Conclusion Compared with 99Tcm-HYNIC-TOC scintigraphy,68Ga-DOTA-TATE PET/CT imaging shows a significantly higher detection rate on small or structure-complex lesions on GEP-NEN patients.