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目的:探讨卡维地洛对急性心肌梗死(AMI)后Sprague-Dawley大鼠心功能的保护作用。方法:用手术结扎左冠脉前降支法,制备50只大鼠AMI模型,随机分为生理盐水组[0.9%NaCl,2 mL/(kg·d)]、福辛普利治疗对照组[3.0mg/(kg·d)]、卡维地洛3治疗组[1.5、3.0、6.0mg/(kg·d)],连续给药4周;另设正常组和假结扎组。进行体重、心率、超声心动图和血浆生化等指标检测。结果:与生理盐水组比较,中、高剂量治疗组大鼠的心率明显降低(P<0.01);超声心动图示EF和FS、IVSd、IVSs均明显增加(P<0.01),LVIDd和LVIDs显著降低(P<0.05);离体心功能示CF、LVSP、LVDP和±dp/dtmax均增加,LVEDP则明显减小(P<0.01);血清中MDA明显降低,而NO、SOD、GSH-PX均增高(P<0.01)。结论:卡维地洛能很好地改善AMI后大鼠的心功能,抑制心室的重构作用。
Objective: To investigate the protective effect of carvedilol on heart function in Sprague-Dawley rats after acute myocardial infarction (AMI). Methods: Fifty rats AMI model were prepared by surgical ligation of left anterior descending coronary artery and were randomly divided into normal saline group (0.9% NaCl, 2 mL / (kg · d)] and fosinopril treatment group [ 3.0mg / (kg · d)], and carvedilol 3 treatment group [1.5,3.0,6.0mg / (kg · d)] for 4 weeks; another normal group and a sham group. Body weight, heart rate, echocardiography and plasma biochemistry and other indicators of detection. Results: Compared with saline group, the heart rate of rats in middle and high dose treatment group was significantly lower (P <0.01); echocardiography showed significantly higher EF and FS, IVSd and IVSs (P <0.01), LVIDd and LVIDs significantly (P <0.01). The serum levels of MDA and NO, SOD, GSH-PX decreased significantly (P <0.05), while the levels of CF, LVSP, LVDP and ± dp / dtmax increased significantly (P <0.01). Conclusion: Carvedilol can improve the cardiac function and inhibit ventricular remodeling after AMI.