Purpose The aim of this study was to describe the clinical and angiographic response of squamo us cell carcinoma (SCC)of the conjunctive to treatment with photodynamic therapy(PDT).Design Interventional case series.Meth-ods In a prospective study,three patients(62to 86years old)with SCC of the conjunctive were trea ted with PDT.Patients received one to three treatments of verteporfin(6mg /m 2 body surface area,intravenously).The light dose was calculated as50J /cm 2 .All tumors were irradiated 1minute after injection.The mean follow -up time was 8.6months(7to 12months).Main outcome measurements were clinical and angiographic resp onse and treatment -related side effects.Results One we ek after treatment,angiographic occlusion of tumor vasculature and normal conjunctival vessels was observed i n all patients.Tumor regression was noted in all patients1month after treat-ment.Two patients had complete regression(clinical and angiographic observation)after one or two treatments for the entire follow-up time.One tumor involved large aspects of the conjunctiva and cornea.In thi s case,only the treated areas showed tumor regression.PDT caused mini-mal temporary local irritation in tw o patients,and small conjunctival hemorrhages and mild t ransient chemosis in the three eyes directly after treatm ent.One patient had infusion -related back pain.Conclu sion The preliminary results of this study suggest that PD T may be a valuable addition to the treatment of patient s with SCC of the con-junctive.However,longer follow -u p is necessary to as-sess the duration and degree of tumor control. Purpose The aim of this study was to describe the clinical and angiographic response of squamo us cell carcinoma (SCC) of the conjunctive to treatment with photodynamic therapy (PDT). Design Interventional case series. Meth ods In a prospective study, three patients ( 62to 86years old) with SCC of the conjunctival were trea ted with PDT. Patients received one to three treatments of verteporfin (6mg / m2 body surface area, intravenously). The light dose was calculated as 50J / cm2. after injection. The mean follow-up time was 8.6 months (7to 12 months). Main outcome measurements were clinical and angiographic resp onse and treatment-related side effects. Results One we ek after treatment, angiographic occlusion of tumor vasculature and normal conjunctival vessels was observed in all patients. Tumor regression was noted in all patients1month after treat-ment.Two patients had complete regression (clinical and angographic observations) after one or two treatments for the enti re follow-up time. One tumor involved large aspects of the conjunctiva and cornea. In thi s case, only the treated areas showed tumor regression. PDA caused mini-mal temporary local irritation in tw o patients, and small conjunctival hemorrhages and mild t ransient chemosis in the three eyes directly after treatm ent. One patient had infusion -related back pain. Conflu sion The preliminary results of this study suggest that PD T may be a valuable addition to the treatment of patient s with SCC of the con-junctive .However, longer follow -up is necessary to as-sess the duration and degree of tumor control.