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目的观察曲美他嗪联合联合前列地尔治疗不稳定型心绞痛的临床疗效。方法2009年12月~2014年12月，357例不稳定型心绞痛患者随机分为三组，每组119例，对照组采用常规治疗，单用组例在对照组基础上加用曲美他嗪治疗，联用组在对照组基础上采用曲美他嗪联合前列地尔治疗，对比观察治疗三组患者的临床疗效。结果单用组的总有效率78.99%，联用组的总有效率为89.92%，均高于对照组的64.70%(<0.05)，联用组的总有效率(89.92%)高于单用组(78.99%)(<0.05)。结论曲美他嗪是一种治疗不稳定型心绞痛治疗方案的有效选择，曲美他嗪同时联合前列地尔治疗，能够明显提高临床疗效.“,”Objective To observe the clil ical ef ct of trimetazidil e jointing alprostadil on the treatment of unstable angina pectoris.Methods 357 cases of patiel ts with unstable angina pectoris from December 2009 to December 2014 were randomly divided into three groups,119 in each group,the control group was given conventional therapy ,alone group was given trimetazidine combined with the control group,while the combination group was given trimetazidine plus alprostadil more,Clinical results in three groups were compared. Results The total clil ical ef ective rate of the alone group was 78.99%the combination group was 89.92%,which was much higher than that of the control group (64.70%)( <0.05),The total clil ical ef ective rate of the combination group (89.92%) was higher than of the alone group (78.99%) ( <0.05). Conclusion Trimetazidine is an ef ective treatment regimen with the treatment of unstable angina pectoris,trimetazidine combined with alprostadil can increase clil ical ef ct obviously.