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目的:探讨乳腺癌患者外周血淋巴细胞中热休克蛋白70(HSP70)表达水平及其临床意义。方法:用Westernblot方法检测45例乳腺癌患者、43例乳腺良性病变患者及43例正常对照组外周血淋巴细胞中HSP70的表达水平。结果:乳腺癌组、乳腺良性病变组外周血淋巴细胞中HSP70表达水平均高于正常对照组,差异有统计学意义(t=2.173,P<0.05);HSP70表达水平在肿瘤直径>2 cm组高于≤2 cm组,差异有统计学意义(t=-2.781,P<0.01);HSP70与乳腺癌患者年龄、组织学分级、临床分期、是否有淋巴结转移及月经状况无关。结论:术前外周血淋巴细胞中HSP70的检测有一定意义,其表达水平有可能成为判断预后的参考指标。
Objective: To investigate the expression of heat shock protein 70 (HSP70) in peripheral blood lymphocytes of breast cancer patients and its clinical significance. Methods: Western blot was used to detect the expression of HSP70 in 45 cases of breast cancer, 43 cases of benign breast lesions and 43 cases of normal control. Results: The expression levels of HSP70 in breast cancer group and benign breast lesions group were significantly higher than those in normal control group (t = 2.173, P <0.05). The expression of HSP70 in the group of tumor diameter> 2 cm The difference was statistically significant (t = -2.781, P <0.01). HSP70 was not associated with age, histological grade, clinical stage, lymph node metastasis and menstrual status in patients with breast cancer. Conclusion: Preoperative detection of HSP70 in peripheral blood lymphocytes has some significance, and its expression level may become a reference index for prognosis.