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目的探讨周围神经高压电击伤后雪旺氏细胞及神经纤维损伤的特点和机理。方法采用高压电击伤家兔模型,观察、测量其坐骨神经在伤后光镜、电镜及雪旺氏细胞DNA定量分析(ICM)的动态变化。结果1轴突、髓鞘持续变性,新生受抑制。2雪旺氏细胞DNA合成在伤后3天启动。3电流在周围神经横断面上分布不均匀。结论雪旺氏细胞DNA合成的迟发启动与轴索、雪旺氏细胞的继发性坏死及新生过程受抑制是周围神经高压电击伤的明显特征。
Objective To investigate the characteristics and mechanism of Schwann cells and nerve fibers injury after peripheral nerve injury caused by high voltage electric shock. Methods Rabbit model of high voltage electric shock was used to observe and measure the dynamic changes of DNA in the sciatic nerve after light injury, light microscope, electron microscope and Schwann cell injury (ICM). Results 1 axons, myelin continued degeneration, inhibition of newborn. 2 Schwann cell DNA synthesis started 3 days after injury. 3 current distribution in the peripheral nerve cross-sectional uneven. Conclusion The delayed onset of DNA synthesis in Schwann cells and axonal degeneration, the secondary necrosis of Schwann cells and the inhibition of neovascularization are the distinguishing features of peripheral nerve injury caused by electrical shock.