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目的观察雷米普利治疗老年收缩期高血压的疗效。方法选择收缩期高血压老年患者86例,给予雷米普利5mg,每日服一次,服药一周后血压仍控制不理想者,剂量可加至10mg,每日一次,治疗8周。结果血压变化在服药1周显效28例,有效34例,无效24例,有效率72.1%,在服药8周,显效38例,有效42例,无效6例,有效率93.1%,治疗前后血压及动态血压变化比较差异显著(P<0.05)。结论雷米普利可24h持续平稳降压,不影响血压昼夜节律。
Objective To observe the efficacy of ramipril in the treatment of senile systolic hypertension. Methods Eighty-six elderly patients with systolic hypertension were given ramipril 5 mg daily for one week. After one week, the blood pressure was not controlled well. The dosage was increased to 10 mg once daily for 8 weeks. Results The changes of blood pressure in one week after taking medicine were effective in 28 cases, effective in 34 cases, ineffective in 24 cases and effective rate in 72.1%. After taking medicine for 8 weeks, 38 cases were markedly effective, 42 cases were effective, 6 cases were ineffective and the effective rate was 93.1% Dynamic blood pressure changes were significantly different (P <0.05). Conclusion Ramipril can be sustained and stable blood pressure 24h, does not affect the circadian rhythm of blood pressure.