家族性肌萎缩性侧索硬化症 (FALS)临床上极少见 ,现报告一家系 3例如下。1　病例　先证者 ,女 ,5 2岁。因四肢无力、变细 1年 ,伴言语不清、吞咽困难 6个月于 2 0 0 3年 5月 2 2日入院。患者于 1年前无明显诱因渐起双下肢无力 ,继而出现双上肢无力 ,四肢变细、肌肉跳动 ,症状进 Familial amyotrophic lateral sclerosis (FALS) clinically rare, is now reported in a family of 3 cases as follows. 1 case proband, female, 5 2 years old. Due to weakness, thinning 1 year, with vague language, difficulty swallowing 6 months in May 2003 2 2 admission. One year ago, no obvious incentive for patients with both lower extremity weakness, followed by weakness in upper extremities, limbs thinning, muscle beating, the symptoms into