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目的:探讨参芪益肺汤对早期尘肺血清中细胞转化生长因子-β1(TGF-β1)的影响。方法:选取尘肺患者60例,随机分为参芪益肺汤加西医常规治疗组(中西药组)和西医常规治疗组(西药组),各30例,同期抽取30名健康人血清做健康对照研究。观察健康人群与尘肺患者血清中TGF-β1的差异;并观察两组尘肺患者治疗前与治疗3个月后TGF-β1、呼吸困难评分MMRC、6min步行距离的变化。结果:健康人群的TGF-β1血清水平显著低于尘肺患者(P<0.01);治疗3个月后中西药组的TGF-β1血清水平与MMRC显著低于西药组(P<0.01),而6min步行距离显著高于西药组(P<0.01)。结论:参芪益肺汤可有效改善早期(气阴两虚、痰瘀阻肺型)尘肺患者的临床症状及肺功能,并有助于降低其血清中的TGF-β1水平。
Objective: To investigate the effect of Shenqi Yifei Decoction on transforming growth factor-β1 (TGF-β1) in early pneumoconiosis serum. Methods: Sixty patients with pneumoconiosis were selected and randomly divided into three groups: 30 cases in each group, and 30 cases in normal control group (Western medicine group) and Western routine treatment group (Western medicine group) . The difference of serum TGF-β1 between healthy people and pneumoconiosis patients was observed. The changes of walking distance of TGF-β1, dyspnea score MMRC, 6min before treatment and 3 months after treatment were observed in two groups of pneumoconiosis patients. Results: Serum levels of TGF-β1 in healthy people were significantly lower than those in patients with pneumoconiosis (P <0.01). Serum levels of TGF-β1 and MMRC in Chinese and Western medicine groups were significantly lower than those in western medicine group after 3 months of treatment (P <0.01) The walking distance was significantly higher than western medicine group (P <0.01). Conclusion: Shenqi Yifei Decoction can effectively improve the clinical symptoms and lung function of patients with pneumoconiosis (Qi and Yin Deficiency, Phlegm and Stasis Lung Type) and reduce the level of TGF-β1 in serum.