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目的:通过对非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)伴慢性前列腺炎(chronic prostatitis,CP)患者的分析,探讨NAFLD与CP之间的联系。方法:收集30例CP伴有NAFLD患者作为NAFLD组;30例CP不伴有NAFLD患者作为CP组,20例健康志愿者作为对照组。检测身高、体重、体质指数(body mass index,BMI)、总胆固醇(total cholesterol,TC)、甘油三酯(triglycerides,TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、丙氨酸转氨酶(alanine transaminase,ALT)等生理指标。镜检各组前列腺液卵磷脂小体密度和白细胞计数;用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测前列腺液中炎症因子IL-6和IL-8。结果:NAFLD组患者CP发病严重程度明显高于CP组,其前列腺液中IL-6和IL-8的分泌明显高于CP组。结论:炎症因子IL-6和IL-8水平异常与NAFLD伴CP密切相关,及早重视男性NAFLD的发病,对于防治CP有重要意义。
Objective: To investigate the association between NAFLD and CP by analyzing patients with non-alcoholic fatty liver disease (NAFLD) and chronic prostatitis (CP). Methods: Thirty ASA patients with NAFLD were enrolled as NAFLD group; 30 AS patients with NAFLD as CP group and 20 healthy volunteers as control group. Body height, weight, body mass index (BMI), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL- Low-density lipoprotein cholesterol (LDL-C), alanine transaminase (ALT) and other physiological indicators. Prostatic fluid lecithin microscopic density and white blood cell count were examined microscopically. Inflammatory cytokines IL-6 and IL-8 in prostatic fluid were detected by enzyme-linked immunosorbent assay (ELISA). Results: The severity of CP in NAFLD group was significantly higher than that in CP group, and the secretion of IL-6 and IL-8 in prostatic fluid was significantly higher than that in CP group. Conclusion: The abnormal levels of inflammatory cytokines IL-6 and IL-8 are closely related to NAFLD and CP, and early attention to the incidence of male NAFLD is of great significance for the prevention and treatment of CP.