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采用脑室给药方法研究了促甲状腺素释放激素（ＴＲＨ）与δ阿片受体特异性拮抗剂ＩＣＩ１７４，８６４合用对失血性休克兔血流动力学指标的影响，旨在探讨ＴＲＨ与ＩＣＩ１７４，８６４是否可配伍用药治疗休克及在ＴＲＨ减量情况下能否起到相应的抗休克作用。ＴＲＨ、ＩＣＩ１７４，８６４两药单用剂量各为５０μｇ，合用剂量各２５μｇ。实验结果显示，ＴＲＨ在剂量减半时与δ阿片受体特异性拮抗剂伍用能够显著改善失血性休克兔心血管功能，特别是左室收缩压（ＬＶＳＰ），与单用相比，差异非常显著（Ｐ＜０．０１）。表明两药可配伍用于治疗休克，且有一定的协同作用
The effect of combination of thyrotrophin releasing hormone (TRH) and δ opioid receptor specific antagonist ICI174,864 on hemodynamics in hemorrhagic shock rabbits was studied by intraventricular administration. The purpose of this study was to investigate whether TRH and ICI174,864 Compatible with drug treatment of shock and TRH reduction in the case can play a corresponding anti-shock effect. TRH, ICI174, 864 two single dose of 50μg each, a combined dose of 25μg. The experimental results showed that TRH could significantly improve the cardiovascular function of rabbits with hemorrhagic shock, especially LVSP, when compared with single opioid receptor specific antagonist at half dose, which was significantly different Significant (P <0.01). Show that the two drugs can be used for the treatment of shock, and have some synergy