Objective: We aimed to study the relationship between clinical efect and surgical methods of inner thigh primary soft tissue sarcomas.Methods: Wide or radical resection were performed in 45 cases of soft tissue sarcomas, including 20 cases of postoperative recurrence after radiation therapy, 7 cases of first treatment. Thirty-six cases received 4-6 cycles of postoperative chemotherapy.Results: Thirty-eight of 45 cases were folowed up for 1-5 years, with 5 case of recurrence and 6 cases of distant metastasis. Conclusion: The inner thigh primary soft tissue sarcoma can be efectively treated with wide or radical resection.