目的:探讨重度子痫前期患者胎盘组织病理学改变对围生儿的影响。方法:选取50例重度子痫前期患者和同期在年龄、孕周匹配且有正常妊娠结局的50例正常对照组产后胎盘组织进行病理检查,对比分析两组胎盘的组织病理学变化。结果:重度子痫前期组与正常对照组相比胎盘梗死灶范围显著增加,差异有统计学意义;早发型重度子痫前期患者胎盘梗死灶范围>30%所占比例较晚发型显著增多,差异有统计学意义(P<0.05)。结论:重度子痫前期患者胎盘梗死灶范围增加,且梗死灶范围对新生儿出生体重有一定影响。 Objective: To investigate the effect of placental histopathological changes on perinatal children in severe preeclampsia. Methods: Fifty patients with severe preeclampsia and 50 normal controls with matched age and gestational age at the same period were enrolled in this study. The placental tissues were collected for histopathological examination. The histopathological changes of placenta were compared between the two groups. Results: The range of placental infarct size in severe preeclampsia group was significantly increased compared with that of the normal control group, the difference was statistically significant. The percentage of placental infarction range> 30% in preeclampsia patients with severe preeclampsia was significantly higher than that in the late onset type, There was statistical significance (P <0.05). Conclusion: The range of placental infarct size increased in patients with severe preeclampsia, and the range of infarct size had a certain impact on birth weight.