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目的探讨平均血小板体积与冠心病患者颈动脉硬化的关系。方法选取2013年4月—2016年4月常州市第一人民医院心内科收治的冠心病患者78例作为观察组(包括急性心肌梗死46例,稳定型心绞痛12例,不稳定型心绞痛20例;单侧病变37例,双侧病变41例);另选取同时期在本院体检健康成年人78例作为对照组。检测并比较两组受试者平均血小板体积和颈动脉内膜中层厚度(CIMT)。结果观察组患者平均血小板体积、CIMT均高于对照组(P<0.05)。不稳定型心绞痛组、急性心肌梗死组患者平均血小板体积、CIMT高于对照组、稳定型心绞痛组(P<0.05);而对照组与稳定型心绞痛组、不稳定型心绞痛组与急性心肌梗死组患者间平均血小板体积、CIMT比较,差异无统计学意义(P>0.05)。颈动脉双侧病变组患者平均血小板体积高于单侧病变组,单侧病变组患者高于对照组(P<0.05)。结论平均血小板体积与冠心病患者颈动脉粥样硬化有关,可作为评估冠心病患者病情严重程度和颈动脉狭窄情况的指标。
Objective To investigate the relationship between mean platelet volume and carotid atherosclerosis in patients with coronary heart disease. Methods From April 2013 to April 2016, 78 patients with coronary heart disease admitted to Department of Cardiology, First People ’s Hospital of Changzhou were selected as observation group (including 46 cases of acute myocardial infarction, 12 cases of stable angina pectoris and 20 cases of unstable angina pectoris) 37 cases of unilateral lesions, bilateral lesions in 41 cases); the same period in our hospital during the selection of 78 healthy adults as a control group. Mean platelet volume and carotid intima-media thickness (CIMT) were measured and compared between the two groups. Results The mean platelet volume and CIMT in observation group were higher than those in control group (P <0.05). The mean platelet volume and CIMT in patients with unstable angina and acute myocardial infarction were significantly higher than those in control group and stable angina pectoris group (P <0.05), while those in stable angina pectoris group, unstable angina pectoris group and acute myocardial infarction group There was no significant difference in mean platelet volume and CIMT among patients (P> 0.05). The average platelet volume in carotid bilateral lesion group was higher than that in unilateral lesion group, and the unilateral lesion group was higher than that in control group (P <0.05). Conclusion The average platelet volume is related to carotid atherosclerosis in patients with coronary heart disease, which can be used as an index to evaluate the severity of disease and carotid artery stenosis in patients with coronary heart disease.