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目的：观察不同剂量葛根芩连汤对2型糖尿病大鼠血糖血脂水平及氧化应激反应的影响，考察其干预2型糖尿病的作用及机理。方法建立高糖高脂联合链脲佐菌素（STZ）诱发的2型糖尿病大鼠模型，观察不同剂量的葛根芩连汤（5g／kg、10 g／kg、20g／kg）对该模型的空腹血糖（FBG）、甘油三酯（TG）、总胆固醇（TCH）、低密度脂蛋白（LDL －C）、高密度脂蛋白（HDL －C）、超氧化物歧化酶（SOD）、丙二醛（MDA）含量的影响。结果与模型对照组比较，葛根芩连汤低、中、高剂量组 FBG 降低（P ＜0．01），SOD 升高（P ＜0．05，P ＜0．01）；葛根芩连汤中、高剂量组 TG 降低（P ＜0．05，P ＜0．01），HDL －C 升高（P ＜0．05，P ＜0．01），MDA 降低（P ＜0．05，P ＜0．01）；葛根芩连汤高剂量组 TCH 降低（P＜0．05），LDL －C 降低（P ＜0．05，P ＜0．01）。结论葛根芩连汤对2型糖尿病大鼠具有降糖降脂的作用，可能是通过增强机体抗氧化能力而实现。“,”s:Objective By observing the effect of different doses of Gegenqinlian decoction in type 2 diabetic rats’ blood lipid levels and the reaction of oxidative stress,the research team investigate the mechanism of it intervene type 2 diabetes.Methods To establish the model of type 2 diabetic rats with high sugar and high fat diet combining STZ -induced, the research team observed the effect of different doses of Gegenqinlian Decoction (5 g/kg, 10 g/kg, 20 g/kg) on the model of fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TCH), low -density lipoprotein (LDL - C), high density lipoprotein (HDL - C), superoxide dismutase (SOD), malondialdehyde (MDA) content.Results The low, medium and high dose of Gegen Qinlian decoction group compared with model control group , FBG de-creased (P <0.01), SOD increased (P <0.05, P <0.01).The medium and high dose group compared with model control group , TG de-creased (P <0.05, P <0.01), HDL increased (P <0.05, P <0.01) and MDA decreased (P <0.05, P <0.01), high dose group compared with model control group , TCH decreased (P <0.05), LDL decreased (P <0.05,P <0.01).Conclusion Gegenqinlian decoc-tion has hypoglycemic and hypolipidemic effects on type 2 diabetic rats,it may be implemented by enhance the capacity of antioxidant .