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近十多年来,亚低温(28℃～35℃)成为治疗颅脑损伤后的一种有效的脑保护措施,不但显著减轻脑损伤后病理损害程度,而且促进神经功能恢复。其主要保护机制包括:保护血脑屏障,减轻脑水肿;降低脑耗氧量和能量代谢,减轻乳酸堆积;抑制内源性有害因子生成和释放,减少脑细胞蛋白破坏;减轻弥漫性轴索损伤等。这种治疗方法的研究进展为临床应用提供了有力的保障。
In the recent ten years, mild hypothermia (28 ℃ ~ 35 ℃) has become an effective brain protection after craniocerebral injury, which not only significantly reduces the degree of pathological damage after brain injury, but also promotes the recovery of nerve function. Its main protective mechanisms include: the protection of the blood-brain barrier, reduce brain edema; reduce brain oxygen consumption and energy metabolism, reduce lactic acid accumulation; inhibit the generation and release of endogenous harmful factors, reduce brain cell protein damage; reduce diffuse axonal injury Wait. The research progress of this treatment method provides a powerful guarantee for clinical application.