关于人胎盘绒毛的内分泌的研究已经有许多报道,但大多是关于神经肽、垂体激素样物质、生长因子和细胞因子方面的研究.单胺类物质报道较少.我们曾首次发现胎盘绒毛滋养层细胞合成5-羟色胺(5-HT),并且5-HT的含量随妊娠时间而变化.多巴胺(DA)和去甲肾上腺素(NE)也是重要的生物胺,它们与性腺激素的合成及分泌关系密切.应用高压液相色谱出(HPLC)和电化学检测仪,我们曾检测到人胎盘绒毛中NE和DA的存在,并通过 There have been many reports about the endocrine of human placental villi, but most of them are about neuropeptides, pituitary hormone-like substances, growth factors and cytokines, few reports of monoamines.We first discovered that placental villous trophoblast Cells synthesize serotonin (5-HT), and the content of 5-HT varies with gestational time.Dopamine (DA) and norepinephrine (NE) are also important biogenic amines, which are involved in the synthesis and secretion of gonadal hormones Closely using high pressure liquid chromatography (HPLC) and electrochemical detector, we have detected the presence of NE and DA in human placental villi and passed