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目的比较老年患者慢性阻塞性肺疾病(慢阻肺)及哮喘-慢性阻塞性肺疾病重叠综合征(ACOS)的临床表现,从而探讨老年ACOS患者的临床特点。方法根据慢阻肺全球创议(GOLD)及ACOS共识中标准,回顾性分析北京友谊医院2012年8月到2016年1月老年病房中COPD及ACOS患者。从患者的一般情况、实验室检查、肺功能、合并症等方面进行临床分析研究。结果本研究共纳入288例COPD患者及101例ACOS患者,平均年龄(81.13±9.6)岁及(1.1±9.5)岁。COPD及ACOS患者SGRQ分别为26.2±5.3,31.5±5.2,ACOS患者指数更高;COPD、ACOS患者中基线FEV1为1.27(0.93,1.71),1.11(0.93,1.45),基线FEV1(%pre)两组之间为65.5±20,59.4±15,基线FEV1/FVC两组之间为59(50.5,65),56.1(50.4,62.7)。两组之间ACOS患者肺功能更差。ACOS患者并发症中心血管疾病、糖尿病、骨质疏松等更多见,发病为52.4%,34.7%,24.7%。结论 ACOS患者较COPD患者,生活质量更差,肺功能下降更明显,心血管疾病并发症多发。
Objective To compare the clinical features of chronic obstructive pulmonary disease (COPD) and asthma - chronic obstructive pulmonary disease (ACOS) in elderly patients with ACOS to explore the clinical features of elderly patients with ACOS. Methods According to GOLD consensus and ACOS consensus criteria, COPD and ACOS patients were retrospectively analyzed in the elderly ward of Beijing Friendship Hospital from August 2012 to January 2016. From the patient’s general situation, laboratory tests, lung function, complications and other aspects of clinical analysis. Results A total of 288 COPD patients and 101 ACOS patients were enrolled in this study. The mean age was 81.13 ± 9.6 years and 1.1 ± 9.5 years. The patients with COPD and ACOS had a significantly higher SGRQ of 26.2 ± 5.3 and 31.5 ± 5.2, respectively, and a higher ACOS index. The COPD and ACOS patients had baseline FEV1 of 1.27 (0.93 and 1.71), 1.11 (0.93 and 1.45) and baseline FEV1 (% pre) 65.5 ± 20,59.4 ± 15 between the groups and 59 (50.5,65), 56.1 (50.4, 62.7) between baseline and FEV1 / FVC. ACOS patients between the two groups had poorer lung function. ACOS patients with cardiovascular disease, diabetes, osteoporosis and other more common, the incidence was 52.4%, 34.7%, 24.7%. Conclusion Compared with patients with COPD, ACOS patients have poorer quality of life, more obvious pulmonary function decline and multiple cardiovascular complications.