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探讨动物失血后肝、脑组织糖皮质激素受体（ＧＲ）的变化及其意义。成年雄性ＳＤ大鼠，麻醉后经颈动脉插管放血０～４０％，或肌注不同剂量的Ｒｕ４８６以阻断组织的ＧＲ０，５０％和８０％。结果：大鼠失血０～４０％后３小时，肝、脑组织胞液ＧＲ量随失血量增加而进行性下降；大鼠失血３０％后０～３小时，肝、脑组织ＧＲ含量随失血持续时间延长而进行性减少；组织ＧＲ与失血量、失血持续时间呈显著的负相关。预先阻断大鼠ＧＲ０、５０％和８０％后再放血１０％，结果ＧＲ阻断率越大，则大鼠颈动脉压越低，时间存活率越小。提示：失血可引起组织ＧＲ减少，失血量越大、失血持续时间越长，ＧＲ减少越明显；ＧＲ可作为反映动物失血严重程度及判断其预后的重要指标
To investigate the changes of glucocorticoid receptor (GR) in liver and brain tissue after blood loss in animals and its significance. Adult male Sprague-Dawley rats were anesthetized and cannulated with carotid artery cannulation for 0-40%, or different doses of Ru486 were injected intramuscularly to block the GR0, 50% and 80% of the tissue. Results: After 3 hours of blood loss from 0 to 40% in rats, the amount of GR in liver and brain cells decreased progressively with the increase of blood loss. The levels of GR in liver and brain increased with blood loss from 0 to 3 hours after 30% Prolonged and progressive reduction; tissue GR and blood loss, blood loss duration was significantly negatively correlated. Pre-blocking rat GR0 50% and 80% and then bleeding 10%, the results of GR block rate, the lower the carotid artery pressure, the smaller the survival rate. Hint: blood loss can cause the reduction of tissue GR, the greater the blood loss, the longer the duration of blood loss, the more obvious the decrease of GR; GR can be used as an important index to reflect the severity of blood loss and prognosis