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肝药酶诱导剂苯巴比妥能诱导细胞色素P-450的合成,而肝药酶抑制剂放线菌素D能抑制细胞色素P-450的合成,本实验应用示差光谱法对P-450含量加以测定.本文改进了传统的计算药后诱导组和抑制组P-450含量增加或减少的百分比来评价药物的方法,在M athem atica数学软件环境下,对数据进行方差分析和t检验,提高了数据处理精度和可信度.并对原方法表示怀疑.
The hepatic drug inducer phenobarbital can induce the synthesis of cytochrome P-450, while the liver enzyme inhibitor actinomycin D can inhibit the synthesis of cytochrome P-450. In this experiment, differential spectroscopy was used to determine the P-450 Content was determined.This paper improved the traditional method to calculate the percentage of P-450 in the induction group and the inhibition group, and analyzed the data by ANOVA and t-test in M athem atica software environment, Improve the accuracy and reliability of data processing, and doubt the original method.