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目的观察食管鳞癌组织中小凹蛋白-1(Caveolin-1)、增殖抗原Ki-67的表达变化,并探讨其临床意义。方法入选食管鳞癌组织110例为试验组,正常食管组织15例为对照组,用免疫组化法检测2组食管组织的Caveolin-1、Ki-67的表达,分析Caveolin-1、Ki-67阳性表达与食管癌临床病理参数的关系。结果试验组低、中、高分化组织中的Caveolin-1阳性表达率分别为47.62%(10/21例),70.91%(39/55例),94.11%(32/34例),对照组Caveolin-1阳性表达率为33.33%(5/15例),差异有统计学意义(P<0.05)。试验组低、中、高分化组织中Ki-67阳性表达率分别为52.38%(11/21例),85.45%(47/55例),97.06%(33/34例),对照组Ki-67阳性表达率为20.00%(3/15例),差异有统计学意义(P<0.05)。Caveolin-1在食管鳞癌中的表达与Ki-67表达呈正相关(r=0.545,P<0.001);Caveolin-1、Ki-67阳性表达均与食管鳞癌分化程度、原发灶-淋巴结-远处转移(TNM)分期、淋巴结转移及肝转移相关(均P<0.05)。结论食管鳞癌组织中Caveolin-1、Ki-67表达升高,其高表达与食管鳞癌分化程度、TNM分期、淋巴结转移及肝转移相关。
Objective To observe the expression changes of Caveolin-1 and Ki-67 in esophageal squamous cell carcinoma and to explore its clinical significance. Methods One hundred and ten esophageal squamous cell carcinoma tissues were selected as experimental group and 15 normal esophageal tissues as control group. The expressions of Caveolin-1 and Ki-67 in two groups of esophageal tissues were detected by immunohistochemistry. Relationship between positive expression and clinical and pathological parameters of esophageal cancer. Results The positive rates of Caveolin-1 in low, moderate and high differentiated tissues were 47.62% (10/21), 70.91% (39/55), 94.11% (32/34) 1 positive rate was 33.33% (5/15 cases), the difference was statistically significant (P <0.05). The positive rates of Ki-67 in low, moderate and well-differentiated tissues in experimental group were 52.38% (11/21), 85.45% (47/55) and 97.06% (33/34), respectively. Ki-67 The positive rate was 20.00% (3/15 cases), the difference was statistically significant (P <0.05). The positive expression of Caveolin-1 in esophageal squamous cell carcinoma was positively correlated with the expression of Ki-67 (r = 0.545, P <0.001). The positive expression of Caveolin-1 and Ki-67 were positively correlated with the differentiation of esophageal squamous cell carcinoma, Distant metastasis (TNM) stage, lymph node metastasis and liver metastasis (all P <0.05). Conclusions The expression of Caveolin-1 and Ki-67 in esophageal squamous cell carcinoma is increased, which is correlated with the differentiation of esophageal squamous cell carcinoma, TNM stage, lymph node metastasis and liver metastasis.