论文部分内容阅读
目的研究膜结合型透明质酸酶(PH-20)mRNA表达与消化道肿瘤侵袭能力及淋巴结转移的关系,探讨其预测肿瘤侵袭危险度的意义。方法采用逆转录聚合酶链反应(RT-PCR)检测59例消化道肿瘤患者的原发癌、癌旁组织、淋巴结转移癌(其中13例)及4例消化道良性病变和各种细胞系(SGC-7901、BGC823、LS-174-T、HCT8、95-D、A549、HFL、HEPG2、L-02)中PH-20mRNA的表达水平。结果PH-20mRNA在上述组织中均有表达,消化道原发癌和淋巴结转移癌均明显高于癌旁组织(P<0.05)。消化道肿瘤PH-20mRNA表达与肿瘤浸润程度有关,浸润性肿瘤的PH-20mRNA表达量高于浅表性肿瘤(P<0.01)。结论PH-20mRNA表达改变可能与消化道肿瘤的发展有关,高表达PH-20mRNA的肿瘤细胞具有高侵袭潜能。
Objective To investigate the relationship between the expression of membrane-bound hyaluronidase (PH-20) mRNA and the invasiveness and lymph node metastasis of gastrointestinal neoplasms and to explore the significance of predicting the risk of tumor invasion. Methods RT-PCR was used to detect primary cancer, paracancer tissues, lymph node metastases (13 of them) and 4 benign lesions of digestive tract and various cell lines SGC-7901, BGC823, LS-174-T, HCT8, 95-D, A549, HFL, HEPG2, L-02). Results The expression of PH-20mRNA in all the above tissues was significantly higher than that in paracancer tissues (P <0.05). The expression of PH-20mRNA in gastrointestinal tumors was related to the degree of tumor invasion. The expression of PH-20mRNA in invasive tumors was higher than that in superficial tumors (P <0.01). Conclusion The change of PH-20mRNA expression may be related to the development of gastrointestinal tumors, and the tumor cells with high expression of PH-20mRNA have high invasive potential.