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目的研究创伤应激对兔的胆汁流量以及血浆胆囊收缩素(cholecystokinin,CCK)、胃泌素 (gastrin,GAS)、促胰液素(secretin,SEC)等肠道激素含量的影响及其关系。方法行胆总管插管引流胆汁计量胆汁流量,将兔双下肢钳断制备应激模型,记录创伤应激前后胆汁流量的变化,同时检测血浆胆囊收缩素、胃泌素、促胰液素的含量。结果创伤应激后兔胆汁流量较应激前明显增多(P<0．01),血浆内胆囊收缩素、胃泌素、促胰液素含量升高(P<0．01)。胆汁流量与胆囊收缩素、胃泌素及促胰液素改变一致 (r=0．65,P<0．05;r=0．63,P<0．05;r=0．73,P=0．01)。结论创伤应激可使兔胆汁流量明显增多, 胃肠激素的变化可能是影响胆汁分泌和排出的重要因素,胆汁流量的增多在临床上能加重胆汁反流,促进应激性溃疡的发生。
Objective To investigate the effects of traumatic stress on the bile flow and the content of intestinal hormones such as cholecystokinin (CCK), gastrin (GAS) and secretin (SEC) in rabbits. Methods The bile flow was measured by bile duct drainage in bile duct. The rabbits were fasted to prepare the stress model. The changes of bile flow before and after trauma stress were recorded. The content of cholecystokinin, gastrin and secretin were also measured. Results The rabbit bile flow rate increased significantly (P <0.01) and the content of cholecystokinin, gastrin and secretin in plasma increased (P <0.01). Bile flow was consistent with changes in cholecystokinin, gastrin and secretin (r = 0.65, P <0.05; r = 0.63, P <0.05; r = 0.73, P = 0 .01). Conclusion Traumatic stress can significantly increase the bile flow in rabbits. The changes of gut hormones may play an important role in the secretion and excretion of bile. Increased bile flow may aggravate bile reflux in clinic and promote the occurrence of stress ulcer.