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目的:研究肺通气功能程度与慢性阻塞性肺疾病患者夜间低氧发生的相关性。方法:选取2012年1月至2013年6月我院治疗的60例稳定期慢性阻塞性肺疾病患者,按肺通气功能分为轻度、中度、重度、极重度4组,每组15例,监测记录研究对象肺通气功能指标及夜间血氧指标,比较各组监测指标的差异,并分析其相关性。结果:不同病情程度COPD患者FEV1/FVC、FEV1、FVC、PEF、RV、RV/TLC、MsaO2、ODI、WsaO2、LsaO2、SIT90%有差异(P<0.05);极重度和重度比较FEV1/FVC、FEV1、RV、MsaO2、ODI、WsaO2、LsaO2、SIT90%有差异(P<0.05);极重度和中度比较FEV1/FVC、FEV1、FVC、PEF、RV、RV/TLC、MsaO2、ODI、WsaO2、LsaO2、SIT90%有差异(P<0.05);极重度和轻度比较FEV1/FVC、FEV1、FVC、PEF、RV、RV/TLC、MsaO2、ODI、WsaO2、LsaO2、SIT90%有差异(P<0.05);重度和中度比较FEV1/FVC、FEV1、FVC、PEF、RV/TLC、MsaO2有差异(P<0.05);重度和轻度比较FEV1/FVC、FEV1、FVC、PEF、RV/TLC、MsaO2、ODI、LsaO2有差异(P<0.05);中度和轻度比较FEV1/FVC、FEV1、FVC、PEF、ODI有差异(P<0.05)。COPD患者的肺通气功能FEV1与MsaO2呈正相关(r=0.683,P<0.05)。结论:肺通气功能程度与慢性阻塞性肺疾病患者夜间低氧发生具有相关性。
Objective: To study the correlation between the degree of pulmonary ventilation and the incidence of nocturnal hypoxia in patients with chronic obstructive pulmonary disease. Methods: Sixty patients with chronic obstructive pulmonary disease (COPD) treated in our hospital from January 2012 to June 2013 were divided into 4 groups according to pulmonary ventilation: mild, moderate, severe and severe, with 15 cases in each group , Monitoring and recording of lung function indicators and nighttime oxygenation indicators of the study object, comparing the differences between the monitoring indicators, and analyze the correlation. Results: FEV1 / FVC, FEV1, FVC, PEF, RV, RV / TLC, MsaO2, ODI, WsaO2, LsaO2 and SIT90% were significantly different in COPD patients with different severity of illness (P0.05); extremely severe and severe FEV1 / FVC, FEV1, FVC, PEF, RV, RV / TLC, MsaO2, ODI, WsaO2, FEV1, RVsa, MsaO2, ODI, WsaO2, LsaO2 and SIT90% LsaO2 and SIT90% (P <0.05). There was a significant difference in extreme and mild FEV1 / FVC, FEV1, FVC, PEF, RV, RV / TLC, MsaO2, ODI, WsaO2, LsaO2 and SIT90% ); FEV1 / FVC, FEV1, FVC, PEF, RV / TLC and MsaO2 were significantly different between severe and moderate groups (P <0.05) , ODI and LsaO2 (P <0.05). There was difference between moderate and mild FEV1 / FVC, FEV1, FVC, PEF and ODI (P <0.05). Pulmonary ventilation FEV1 was positively correlated with MsaO2 in patients with COPD (r = 0.683, P <0.05). Conclusion: The degree of pulmonary ventilation is correlated with nocturnal hypoxia in patients with chronic obstructive pulmonary disease.