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肿瘤的发生过程中,除了能量代谢外,肿瘤的生物合成代谢与人体正常组织也有很大不同,具体表现在核苷酸、脂质和蛋白质的生物合成这3个方面。肿瘤细胞的生物合成能力明显强于正常细胞,但它的合成途径和方式又不同于正常细胞,其主要以从头合成为主,明显强于正常细胞,且这种生物合成能力的增强往往是以牺牲机体其他细胞为代价的。对肿瘤不同的生物合成途径的研究既是挑战也是机遇,弄清肿瘤细胞生物合成的机制,对肿瘤早期诊断和靶向治疗具有重要的意义。
In addition to the energy metabolism, tumor biosynthesis and metabolism are also very different from the normal human tissues in the process of tumor development, which is manifested in the three aspects of nucleotide, lipid and protein biosynthesis. The biosynthesis ability of tumor cells is obviously stronger than that of normal cells, but its synthesis pathway and method are different from normal cells, which are mainly de novo synthesis and obviously stronger than normal cells, and the enhancement of this biosynthesis ability is often based on At the expense of other cells at the expense of the body. The study of different biosynthetic pathways in tumor is not only a challenge but also an opportunity to clarify the mechanism of tumor cell biosynthesis and is of great significance to the early diagnosis and targeted therapy of tumors.