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目的:探讨彩色多普勒超声评价无水酒精治疗肝细胞癌早期疗效的临床应用价值。方法:利用彩色多普勒血流显像(CDFI)、彩色多普勒能量图(CDE)检查技术,经皮无水酒精瘤内注射(PEI)治疗52例肝细胞癌(肿块直径1.65.0cm),疗程结束后一周,以CDFI及CDE血流显示的有无作为评价PEI早期疗效的观察指标,并行组织学活检病理检查。结果:52个肿块经PEI治疗后,CDFI及CDE示大部分肿块血流信号消失,小部分肿块能检出血流信号,但较治疗前明显减少。以病理检查结果为金标准,CDFI及CDE评价PEI治疗后肿瘤的灭活情况,其敏感性为:50.0%、77.8%,准确性为78.8%、90.4%,Kappa值为:0.486、0.779。结论:CDFI、CDE动态监控PEI治疗过程对指导治疗意义重大,CDFI、CDE评价PEI结果客观、可靠,CDE可以敏感而直观地显示PEI治疗后肿瘤周边及内部残存的血流信号,对指导PEI治疗、时机及靶目标的选择以提高疗效具有重要的临床应用价值。
Objective: To evaluate the clinical value of color Doppler ultrasound in evaluating the early curative effect of anhydrous alcohol on hepatocellular carcinoma. Methods: Fifty-two patients with hepatocellular carcinoma (mass diameter 1.65.0cm) were treated with CDFI and CDE, and percutaneous ethanol injection (PEI) ), One week after the course of treatment, whether CDFI and CDE blood flow was used as an indicator to evaluate the early efficacy of PEI, and pathological examination of histological biopsy. Results: After treated with PEI in 52 tumors, CDFI and CDE showed that most of the tumors showed disappearance of blood flow signals, and a small number of tumors showed blood flow signals, which were significantly lower than those before treatment. The pathological results of gold as the standard, CDFI and CDE evaluation of PEI treatment of tumor inactivation, the sensitivity was: 50.0%, 77.8%, the accuracy of 78.8%, 90.4%, Kappa values: 0.486,0.779. Conclusions: CDFI and CDE dynamically monitor the course of PEI. The evaluation of PEI by CDFI and CDE is objective and reliable. CDE can sensitively and directly show the remaining blood flow signals around and within the tumor after PEI. , Timing and target selection in order to improve the efficacy has important clinical value.