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目的:研究复方米非司酮(每片含米非司酮30mg+双炔失碳酯5mg)对终止早期妊娠的疗效与副作用,以及加用妇科止血灵的疗效。方法:选择因非意愿妊娠要求终止妊娠的孕<49d的妇女239例,利用随机数将患者分成单方米非司酮组(80例,给予米非司酮50mg,bid×3d)、复方米非司酮组(80例,给予复方米非司酮1片,qd×2d)和妇科止血灵组(79例,给予复方米非司酮1片,qd×2d+妇科止血灵5片,tid×3d),3组均于末次服药后给予米索前列醇促进孕囊排出。结果:复方米非司酮组和妇科止血灵组流产成功率分别为92.50%(74/80)和92.41%(73/79),而单方米非司酮组为77.50%(62/80);另外,应用复方米非司酮的2组,孕囊排出时间、出血量及出血时间均明显小于单方米非司酮组,妇科止血灵组出血量及出血时间小于复方米非司酮组。3组在副作用方面则均无统计学差异。结论:复方米非司酮与单方米非司酮相比可加快孕囊排出时间,减少出血量,提高流产成功率,同时具有用药简便,用药剂量小的特点,而加用妇科止血灵则进一步减少出血量和转经天数。
Objective: To study the curative effect and side effect of compound mifepristone (each tablet containing mifepristone 30mg + anordrin) 5mg on the termination of early pregnancy and the curative effect of adding gynecological bleeding medicine. METHODS: A total of 239 women of preg- nant <49 days who had their pregnancies discontinued due to unwanted pregnancies were enrolled. Patients were randomized to a single mifepristone group (n = 80, given mifepristone 50 mg bid twice a day) (80 cases, given a compound mifepristone, qd × 2d) and gynecological jie Ling group (79 cases, given mifepristone 1, qd × 2d + gynecological bleeding Ling 5, tid × 3d ), 3 groups were given misoprostol after the last dose to promote the discharge of gestational sac. Results: The success rates of abortion in the compound mifepristone group and the gynecological jinglingling group were 92.50% (74/80) and 92.41% (73/79), respectively, while those in the mifepristone group were 77.50% (62/80). In addition, the application of compound mifepristone group 2, gestational sac discharge time, bleeding and bleeding time were significantly less than unilateral mifepristone group, gynecological bleeding group bleeding and bleeding time is less than the compound mifepristone group. There were no significant differences in side effects among the three groups. Conclusion: Compared with unilateral mifepristone, mifepristone can accelerate the time of gestational sac excretion, reduce the amount of bleeding and improve the success rate of abortion, at the same time, it has the characteristics of simple medication and small dosage, Reduce the amount of bleeding and menstruation days.