目的：探讨胰腺癌细胞凋亡相关基因表达及与ＥＲ、ＰＲ表达的关系。方法：本文用免疫组织化学ＳＰ法检测ｂｃｌ２，ｐ５３和ｃｍｙｃ基因在胰腺癌和胰腺癌转移灶中的表达。结果显示：ｂｃｌ２蛋白在胰腺癌组明显高于胰腺癌转移灶组；无转移的、高分化的胰腺癌明显高于有转移的和低分化胰腺癌。ｐ５３蛋白在胰腺癌组明显高于胰腺良性病变组，胰腺高分化癌明显低于胰腺低分化癌。ｂｃｌ２和ｐ５３蛋白在胰腺癌组中呈负相关。胰腺癌组ｂｃｌ２蛋白与ＥＲ表达呈正相关。结论：ｂｃｌ２和ｐ５３蛋白的表达特征可以反映胰腺癌生物学行为。 Objective: To investigate the expression of apoptosis-related genes in pancreatic cancer cells and their relationship with the expression of ER and PR. Methods: Immunohistochemical SP method was used to detect the expression of bcl2, p53 and cmyc genes in pancreatic and pancreatic cancer metastases. The results showed that bcl2 protein was significantly higher in the pancreatic cancer group than in the pancreatic cancer metastasis group; no metastatic, well-differentiated pancreatic cancer was significantly higher than that of metastatic and poorly differentiated pancreatic cancer. The p53 protein was significantly higher in the pancreatic cancer group than in the benign pancreatic tumor group. The pancreatic well-differentiated carcinoma was significantly lower than the pancreatic poorly differentiated carcinoma. The bcl 2 and p53 proteins were negatively correlated in the pancreatic cancer group. There was a positive correlation between bcl-2 protein and ER expression in pancreatic cancer. Conclusion: The expression of bcl2 and p53 protein can reflect the biological behavior of pancreatic cancer.