宿主防御机制可能参与恶性疾病的药物治疗。氨甲喋呤(Methotrexate)在体外增强淋巴细胞对植物血球凝集素和对免疫活性细胞的母细胞形成反应。某些恶性肿瘤,单核细胞浸润的有否,可以断定对氨甲喋呤的临床反应。浸润越厉害肿瘤对氨甲喋呤的反应好象就越大。对这种情况进行推测是很有兴趣的,即氨甲喋呤除了它自己直接对肿瘤的作用以外, Host defense mechanisms may be involved in the treatment of malignant diseases. Methotrexate enhances lymphocyte formation in vitro in response to phytohemagglutinin and blast cells in immunocompetent cells. Some malignant tumors, whether mononuclear cell infiltration, can determine the clinical response to methotrexate. The more aggressive the tumor, the more it responds to methotrexate. It is interesting to speculate on this situation, that is, methotrexate in addition to its own direct effect on the tumor.