Fick于1870年介绍了测量心输出量的稀释法,成为基础科学和心脏病学史上最重要的事件之一。虽然Fick估算了氧摄量和动静脉血氧差,而且计算了人的心输出量的合理值,但是他自己却从未使用过稀释法。Fick用氧气作为指示剂,但很快就出现了其他的指示剂,第一个就是盐水,由Stewart于1897年提出的。静脉注射盐水会使动脉血液电阻 Fick introduced the dilution method of measuring cardiac output in 1870 and became one of the most important events in the history of basic science and cardiology. Although Fick estimated oxygen and arteriovenous oxygen differences, and calculated a reasonable value for a person’s cardiac output, he never used the dilution method himself. Fick used oxygen as an indicator, but other indicators soon appeared, the first being brine, proposed by Stewart in 1897. Intravenous saline causes arterial blood resistance