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目的:应用数学模拟研究中药制剂原料吸湿动力学模型,从动力学角度分析中药制剂原料吸湿特性。方法:测定中药制剂原料的吸湿性,分别采用Fick第一扩散定律、一级渐进模型、Peleg模型、Fick第二扩散定律进行拟合。结果:中药制剂原料吸湿过程符合Fick扩散定律,可采用Peleg模型拟合中药制剂原料的吸湿动力学,模型与平衡吸湿量和初始吸湿量呈负相关。蓝芩方提取物、双黄连方提取物、山菊降压方提取物、乐脉方提取物、玄麦甘桔方提取物、野菊花提取物、川参方提取物、康心宁方提取物、安神养心方提取物的预测值与实际值间相似度分别为0.999 6,0.995 9,0.999 2,0.927 1,0.995 7,0.998 8,0.999 1,0.919 8,0.979 6,扩散系数依次为1.16×10-7,1.74×10-3,3.06×10-3,2.62×10-3,2.16×10-3,2.48×10-3,2.23×10-3,2.85×10-3,2.64×10-3。结论:通过数学模拟探析吸湿动力学过程可较好地解释中药制剂原料的吸湿机制。
OBJECTIVE: To study the hygroscopic kinetic model of raw materials of traditional Chinese medicine by mathematical simulation and to analyze the hygroscopicity characteristics of raw materials of traditional Chinese medicine from the viewpoint of kinetics. Methods: The hygroscopicity of the raw materials of Chinese traditional medicine was determined. Fick’s first diffusion law, first-order progressive model, Peleg model and Fick’s second diffusion law were fitted respectively. Results: The hygroscopic process of raw materials of Chinese traditional medicine complied with Fick ’s law of diffusion. The Peleg model was used to fit the hygroscopic kinetics of the raw materials of Chinese traditional medicine. The model was negatively correlated with the equilibrium moisture content and initial moisture absorption. Radix Scutellariae extract, Shuanghuanglian Fang extract, Shan Ju antihypertensive extract, Lemai extract, Xuanmai Gan Ju Fang extract, wild chrysanthemum extract, Chuansenfang extract, Kang Xin Ning Fang extract, soothe the nerves The similarities between the predicted value and the actual value of Yang Xin Fang extract were 0.999 6,0.995 9,0.999 2,0.927 1,0.995 7,0.998 8,0.999 1,0.919 8,0.979 6 respectively, the diffusion coefficients were 1.16 × 10 -1.74 × 10 -3, 3.06 × 10 -3, 2.62 × 10 -3, 2.16 × 10 -3, 2.48 × 10 -3, 2.23 × 10 -3, 2.85 × 10 -3, 2.64 × 10 -3 . Conclusion: The hygroscopic kinetic process through mathematical simulation can better explain the hygroscopic mechanism of raw materials of traditional Chinese medicine.