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目的探讨凋亡抑制基因survivin在大肠癌的表达,及在大肠癌发展、转移等生物学特性中的作用。方法收集大肠癌组织62例和25例正常大肠组织,用免疫组织化学SP法检测survivin的表达情况。结果62例大肠癌组织,35例sur-vivin表达阳性,大肠癌组织阳性表达率为56.4%,而在正常大肠组织中不表达。而且与肿瘤的病理分期、淋巴结转移显著相关(P<0.05),与浸润深度没有显著性差异(P>0.05)。结论Survivin基因在大肠癌中呈高表达,检测survivin基因的表达可以预测大肠癌的恶性程度和预后。
Objective To investigate the expression of survivin gene in colorectal carcinoma and its role in the development and metastasis of colorectal carcinoma. Methods Colorectal cancer tissues were collected from 62 cases and 25 cases of normal colorectal tissues. The expression of survivin was detected by immunohistochemical SP method. Results The positive expression rate of sur-vivin in 62 cases of colorectal cancer tissues and 35 cases of colorectal cancer tissues was 56.4%, but not in normal colorectal tissues. But also significantly correlated with pathological stage and lymph node metastasis (P <0.05), but not with depth of invasion (P> 0.05). Conclusion Survivin gene is highly expressed in colorectal cancer. Survivin gene expression can predict the malignancy and prognosis of colorectal cancer.