肝活检是诊断肝纤维化的金标准,但其为创伤性的,且有局限性。肝纤维化和肝硬化的非创伤性诊断方法有:血清学诊断、影像学诊断和肝脏弹性检测等。肝纤维化的血清学诊断指标包括:反映细胞外基质分泌的指标、细胞因子、蛋白聚糖及反映肝生化功能的标志。肝纤维化非创伤性生化标志综合模型是目前的研究热点。本文对血清生化标志综合模型评估肝纤维化的现状作一综述。 Liver biopsy is the gold standard for diagnosing liver fibrosis, but it is traumatic and has limitations. Noninvasive diagnostic methods for liver fibrosis and cirrhosis include serodiagnosis, imaging diagnosis and liver elasticity testing. Serological diagnosis of liver fibrosis indicators include: the indicators reflect the secretion of extracellular matrix, cytokines, proteoglycans and reflect the biochemical markers of liver. Hepatic fibrosis non-invasive biochemical markers integrated model is the current research focus. This review summarizes the status of liver fibrosis assessed by a comprehensive model of serum biochemical markers.