疟疾是一种全球性疾病,仍然威胁着人类的健康和生命。目前,疟原虫除了对青蒿素类未产生明显耐药性外,几乎对所有常规抗疟药都产生了抗性,然而新抗疟药的研制需要足够长的时间周期。近年来,能否在现有的非常规抗疟药物当中发现具有抗疟作用的药物,成为研究疟疾治疗的热点之一。本文对这些药物及其新近的研究进展做一综述。 Malaria is a global disease that still threatens human health and life. Currently, Plasmodium is almost resistant to all conventional antimalarials except that it does not show significant resistance to artemisinin, however, the development of new antimalarial drugs requires a sufficiently long period of time. In recent years, whether or not antimalarial drugs have been found in the existing unconventional antimalarial drugs has become one of the hot topics in the research of malaria treatment. This article reviews the progress of these drugs and their recent research.