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应用放射免疫分析法测定了４０例老年脑梗塞患者血浆内皮素（ＥＴ１）水平，并对另１０例缓慢进展型脑梗塞患者做了动态观察，结果发现老年脑梗塞患者血浆ＥＴ１水平显著高于对照组（Ｐ＜０．０１），并与病情轻重有关，其重度脑梗塞患者血浆ＥＴ１水平（１８．８±４．３ｐｇ／ｍｌ）明显高于轻、中度者（１５．３±３．６ｐｇ／ｍｌ），Ｐ＜０．０５；缓慢进展型脑梗塞患者血浆ＥＴ１水平随发病时间延长而递增，提示ＥＴ１可能是老年脑梗塞发病和进展过程的重要因素。
Radioimmunoassay was used to determine plasma endothelin (ET1) levels in 40 elderly patients with cerebral infarction. Dynamic changes were observed in 10 patients with slowly progressive cerebral infarction. ET1 levels in elderly patients with cerebral infarction were significantly higher than those in controls (P <0.01). The ET1 level in patients with severe cerebral infarction (18.8 ± 4.3pg / ml) was significantly higher than that in patients with mild to moderate (15.3 ± 3.6pg / Ml), P <0.05; plasma ET1 levels in patients with slowly progressing cerebral infarction increased with time, suggesting that ET1 may be an important factor in the pathogenesis and progression of cerebral infarction in the elderly.