系统性红斑狼疮(SLE)是一种以多脏器受累和血液中存在多种自身抗体为特征的自身免疫性疾病。许多研究证实T、B淋巴细胞过度活化导致致病性自身抗体的产生,是其发病机制的关键环节[1],我们应用非清髓化疗结合自体外周血干细胞移植治疗了3例合并肾脏损害(狼疮性肾炎Ⅳ型)、心脏损 Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ involvement and multiple autoantibodies present in the blood. Numerous studies have confirmed that T and B lymphocyte over-activation leads to the production of pathogenic autoantibodies and is a key link in its pathogenesis [1]. We used non-myeloablative chemotherapy combined with autologous peripheral blood stem cell transplantation to treat 3 patients with renal damage Lupus nephritis Ⅳ), heart damage