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目的观察动脉灌注介入化疗对局部晚期宫颈癌的治疗效果。方法 38例Ⅰb2期和Ⅱa期宫颈癌患者中16例行术前子宫动脉灌注介入化疗,用顺铂80mg/m2,化疗2～3疗程。每次介入治疗间隔10～14d。化疗后3～4周行广泛子宫切除术+盆腔淋巴结清扫术。22例直接行广泛子宫切除术+盆腔淋巴结清扫术两种治疗方法。结果 16例患者经介入化疗后CR4例,PR10例,总有效率为87.5%。所有患者化疗后均行手术切除。与直接手术患者比较,手术时间和出血量明显减少(P<0.05,P<0.005),术后病理发现肿瘤深肌浸润明显减少(P<0.05)。结论介入治疗对局部晚期以上宫颈癌有一定的近期疗效,可以提高手术切除率,是宫颈癌综合治疗的有效手段之一。
Objective To observe the therapeutic effect of arterial infusion chemotherapy on locally advanced cervical cancer. Methods Thirty-six patients with stage Ⅰb2 and Ⅱa cervical cancer underwent preoperative uterine arterial infusion chemotherapy, with cisplatin 80mg / m2 and chemotherapy for 2 ~ 3 courses. Interventional treatment interval of 10 ~ 14d. 3 to 4 weeks after chemotherapy, extensive hysterectomy + pelvic lymph node dissection. 22 cases of direct hysterectomy + pelvic lymph node dissection of two treatment methods. Results 16 patients after CR4 interventional chemotherapy, PR10 cases, the total effective rate was 87.5%. All patients underwent surgical resection after chemotherapy. Compared with direct surgery patients, the operation time and bleeding volume were significantly reduced (P <0.05, P <0.005), and the postoperative pathological findings were significantly decreased (P <0.05). Conclusion Interventional therapy has some short-term curative effect on locally advanced cervical cancer, which can improve the rate of surgical resection and is one of the effective methods for comprehensive treatment of cervical cancer.