Danazol(17α-娠烷-2,4-二烯-20-炔基〔2,3d〕异(口恶)唑-17-醇)是一种合成的雄性激素,其雄性作用已被减弱。本药开始用于子宫内膜异位症,后来发现它对乳房的囊性疾病有效,并能预防遗传性血管神经性水肿的发作。本药还可用来治疗性早熟、男性乳腺增生症、月经过多和α_1-抗胰蛋白酶缺乏症等。 Ahn等人和Gralnick等人分别报导了用Danazol来治疗22例特发性血小板减少性紫癜(ITP)和5例血友病患者。 22例ITP患者均经糖皮质激素治疗但未能完全缓解。其中15例已切脾,18例曾先后或正在进行其它治 Danazol is a synthetic androgenetic hormone whose male action has been attenuated. The drug began to be used for endometriosis, and later found to be effective in cystic diseases of the breast and to prevent the onset of hereditary angioedema. The drug can also be used to treat precocious puberty, men’s hyperplasia, menorrhagia and α_1-antitrypsin deficiency and so on. Ahn et al. And Gralnick et al. Reported on the use of Danazol for the treatment of 22 idiopathic thrombocytopenic purpura (ITP) and 5 hemophilia patients, respectively. Twenty-two patients with ITP were treated with glucocorticoid but did not achieve complete remission. Among them, 15 cases had splenectomy and 18 cases had or had undergone other treatments