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目的研究癌基因蛋白ERBB2在胃癌组织中过表达情况,并观察其临床意义。方法65例不同病理类型的胃癌组织及25例正常的癌旁组织(对照组)进行ERBB2过表达的免疫组织化学染色,其表达结果与临床资料进行对比分析。结果65例胃癌组织ERBB2过表达者8例,占12.3%;而癌旁正常胃组织未见ERBB2过表达(P<0.01)。其中肠型胃癌7例,占该型胃癌的16.3%(7/43);弥散型胃癌1例,占该型胃癌的4.5%(1/22);两者相差非常显著(P<0.01)。ERBB2过表达与胃癌TNM分期相关联,TNM分期越差者,其阳性率越高。结论癌基因蛋白ERBB2在胃癌组织中过表达,在不同病理类型的胃癌中所起作用可能不同。
Objective To investigate the overexpression of oncogene protein ERBB2 in gastric cancer and to observe its clinical significance. Methods 65 patients with different pathological types of gastric cancer tissues and 25 normal paracancerous tissues (control group) were immunohistochemically stained for ERBB2 overexpression, and their expression was compared with clinical data. Results The overexpression of ERBB2 in 65 cases of gastric cancer tissues was found in 8 cases (12.3%), while no ERBB2 overexpression was found in adjacent normal gastric tissues (P <0.01). Seven cases were intestinal type of gastric cancer, accounting for 16.3% (7/43) of the type of gastric cancer; one case of diffuse type gastric cancer, accounting for 4.5% (1/22) of the type of gastric cancer. The difference was significant (P <0.01). The overexpression of ERBB2 is associated with the TNM staging of gastric cancer. The worse the TNM staging, the higher the positive rate. Conclusion The overexpression of oncogene protein ERBB2 in gastric cancer tissue may play different roles in different pathological types of gastric cancer.