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目的:在儿童晚期肿瘤患者中观察复方苦参注射液作为化疗辅助药物的疗效。方法:57例患者随机分为两组,即化疗加复方苦参注射液组(治疗组)29例,和单纯化疗组(对照组)28例,比较两组化疗相关消化和血液系统急性毒性的发生、外周血的恢复和疼痛症状的变化。结果:ⅡI、IV级消化和血液系统急性毒性的发生,治疗组为21%和41%,低于对照组的39%和57%。外周血ANC和plt恢复时间治疗组为11.3天和12.6天,短于对照组的13.9天和15.7天。结论:复方苦参注射液减轻化疗相关消化和血液系统急性毒性。
OBJECTIVE: To observe the efficacy of Compound Kushen Injection as adjuvant medicine for chemotherapy in children with advanced cancer. Methods: A total of 57 patients were randomly divided into two groups: chemotherapy plus compound Kushen injection group (treatment group) in 29 cases and chemotherapy alone group (control group) in 28 cases. Comparison of chemotherapy-related digestion and acute toxicity of hematological system between the two groups Occurrence, recovery of peripheral blood and changes in pain symptoms. RESULTS: Grade III, IV digestion and acute toxicity of the blood system occurred in the treatment group at 21% and 41%, which was lower than the control group of 39% and 57%. The recovery time of ANC and plt in peripheral blood was 11.3 days and 12.6 days in the treatment group, which was shorter than the 13.9 days and 15.7 days in the control group. Conclusion: Compound Kushen injection can reduce chemotherapy-related digestion and acute toxicity of blood system.