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目的探讨非诺贝特对非酒精性脂肪性肝病的临床疗效。方法选择河南省驻马店市第二人民医院2006-01-2009-01门诊或住院患者96例非酒精性脂肪性肝病,随机分为两组,分别给予非诺贝特100 mg,3次/d和藻酸双酯钠100 mg,3次/d,口服,疗程4个月,于治疗前后用B型超声波检查肝脏情况。结果非诺贝特组脂肪肝恢复状况显著高于藻酸双酯钠组,总有效率分别为93.8%和75.0%(P<0.05)。结论非诺贝特对非酒精性脂肪性肝病较藻酸双酯钠有更好的疗效。
Objective To investigate the clinical effect of fenofibrate on nonalcoholic fatty liver disease. Methods A total of 96 non-alcoholic fatty liver disease outpatients or inpatients were selected from the Second People’s Hospital of Zhumadian City, Henan Province from January 2006 to January 2009 with or without fenofibrate 100 mg, Sodium alginate 100 mg, 3 times / d, orally, for 4 months, before and after treatment with B ultrasound examination of the liver. Results The recovery of fatty liver in fenofibrate group was significantly higher than that in sodium alginate group, the total effective rates were 93.8% and 75.0%, respectively (P <0.05). Conclusion Fenofibrate has better efficacy than sodium alginate in nonalcoholic fatty liver disease.